![]() It was previously demonstrated that PRIMA‑1 met effectively inhibited the growth of colorectal cancer (CRC) cells in a p53‑independent manner, and distinctly induced apoptosis by upregulating Noxa in p53‑mutant cell lines. P53‑reactivation and induction of massive apoptosis‑1, APR‑017 methylated (PRIMA‑1 met APR246) targets mutant p53 to restore its wild‑type structure and function.
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